Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1974 Jun;71(6):2169-73.
doi: 10.1073/pnas.71.6.2169.

Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species

R W Hart, R B Setlow
Comparative Study

Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species

R W Hart et al. Proc Natl Acad Sci U S A. 1974 Jun.

Abstract

The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision-repair) after UV irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of [(3)H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, man). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.

PubMed Disclaimer

References

    1. J Gerontol. 1966 Jul;21(3):404-9 - PubMed
    1. J Cell Biol. 1966 Apr;29(1):11-9 - PubMed
    1. Prog Nucleic Acid Res Mol Biol. 1968;8:257-95 - PubMed
    1. Radiat Res. 1969 Feb;37(2):334-48 - PubMed
    1. Radiat Res. 1969 Mar;37(3):451-66 - PubMed

Publication types

MeSH terms

LinkOut - more resources