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. 1974 Jul;71(7):2600-4.
doi: 10.1073/pnas.71.7.2600.

Growth control in cultured mouse fibroblasts: induction of the pleiotypic and mitogenic responses by a purified growth factor

P S Rudland, W Seifert, D Gospodarowicz

Growth control in cultured mouse fibroblasts: induction of the pleiotypic and mitogenic responses by a purified growth factor

P S Rudland et al. Proc Natl Acad Sci U S A. 1974 Jul.

Abstract

Addition of serum to quiescent mouse fibroblasts induces a series of macromolecular changes (a pleiotypic response) followed by DNA synthesis and cell division. A new pituitary hormone, fibroblast growth factor, and hydrocortisone acting at physiological concentrations can completely replace exogenously added serum for the induction of these events in lines of BALB/c 3T3 cells. The induction of cell growth is specific for cultured fibroblasts; no stimulation is observed for mouse epithelial cells or virally transformed fibroblasts.

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