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. 1974 Dec;71(12):4693-7.
doi: 10.1073/pnas.71.12.4693.

Sites of acetylation of sickle cell hemoglobin by aspirin

M Shamsuddin, R G Mason, J M Ritchey, G R Honig, I M Klotz

Sites of acetylation of sickle cell hemoglobin by aspirin

M Shamsuddin et al. Proc Natl Acad Sci U S A. 1974 Dec.

Abstract

Aspirin acetylates a variety of sites on both the alpha and beta chains of hemoglobin S. Nevertheless, the vast majority of acetyl groups become attached to three loci: betaLys 59, betaLys 144, and alphaLys 90. These observations reveal some molecular details of this transacylation reaction and suggest interesting possibilities for its extension to other acylsalicylates with a variety of different structures.

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References

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