Dye clearance studies in Rotor's syndrome
- PMID: 453129
Item in Clipboard
Dye clearance studies in Rotor's syndrome
Am J Gastroenterol.
1979 Apr.
Abstract
Plasma clearances of sulfobromophthalein sodium (BSP), indocyanine green (ICG) and unconjugated bilirubin were studied in six patients with Rotor's syndrome. A marked retention of these three substances in the plasma was observed. At 60 minutes after injection, serum BSP consisted almost entirely of the unconjugated form. In three patients, BSP Tm and BSP S were significantly reduced. Clearance of unconjugated bilirubin was markedly impaired. This, together with the conjugated hyperbilirubinemia may be interpreted to reflect reduced storage. These results indicate that Rotor's syndrome is marked by reduced hepatic storage capacity and excretory function of BSP, ICG and bilirubin.
Similar articles
-
Nine cases with marked retention of indocyanine green test and normal sulfobromophthalein test without abnormal liver histology: constitutional indocyanine green excretory defect.Hepatogastroenterology. 1981 Feb;28(1):6-12. Hepatogastroenterology. 1981. PMID: 7216141
-
Hepatic transport of serum bilirubin, bromsulfophthalein, and indocyanine green in patients with congenital non-hemolytic hyperbilirubinemia and patients with constitutional indocyanine green excretory defect.J Gastroenterol. 1996 Apr;31(2):228-36. doi: 10.1007/BF02389522. J Gastroenterol. 1996. PMID: 8680543
-
Comparison of sulfobromophthalein and indocyanine green clearances in the cat.Am J Vet Res. 1983 Apr;44(4):727-30. Am J Vet Res. 1983. PMID: 6869973
-
Abnormal hepatic transport of indocyanine green in Gilbert's syndrome.Gastroenterology. 1976 Mar;70(3):385-91. Gastroenterology. 1976. PMID: 814028 Review.
-
Hepatic transport and metabolism of various organic anions in patients with congenital non-hemolytic hyperbilirubinemia, including constitutional indocyanine green excretory defect.J Gastroenterol. 1994 Apr;29(2):228-40. doi: 10.1007/BF02358689. J Gastroenterol. 1994. PMID: 8012515 Review. No abstract available.
Cited by
-
Clinical significance of plasma endothelin-1 in patients with chronic liver disease.Dig Dis Sci. 1994 Dec;39(12):2665-70. doi: 10.1007/BF02087707. Dig Dis Sci. 1994. PMID: 7995194
-
Serum bile acids and oral ursodeoxycholic acid tolerance test in the diagnosis of esophageal varices.Gastroenterol Jpn. 1987 Oct;22(5):614-20. doi: 10.1007/BF02776722. Gastroenterol Jpn. 1987. PMID: 3678732
-
Partial defect in hepatic glutathione S-transferase activity in a case of Rotor's syndrome.Gastroenterol Jpn. 1987 Feb;22(1):34-8. doi: 10.1007/BF02806332. Gastroenterol Jpn. 1987. PMID: 2952540
-
The hepatic excretion of 131I-rose bengal and 99mTc-IDA derivatives in Rotor's syndrome.Eur J Nucl Med. 1982;7(7):311-7. doi: 10.1007/BF00253427. Eur J Nucl Med. 1982. PMID: 6896856
-
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.J Clin Invest. 2012 Feb;122(2):519-28. doi: 10.1172/JCI59526. Epub 2012 Jan 9. J Clin Invest. 2012. PMID: 22232210 Free PMC article.