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. 1973 Feb 1;137(2):543-6.
doi: 10.1084/jem.137.2.543.

Proliferation of donor marrow and thymus cells in the myeloid and lymphoid organs of irradiated syngeneic host mice

A Takada, Y Takada

Proliferation of donor marrow and thymus cells in the myeloid and lymphoid organs of irradiated syngeneic host mice

A Takada et al. J Exp Med. .

Abstract

CBA/HT(6)T(6) bone marrow cells (1 x 10(7)) or CBA/H bone marrow cells (1 x 10(7)) plus CBA/HT(6)T(6) thymus cells (5 x 10(7)) were injected intravenously into lethally (800 R) irradiated CBA/H mice. Chromosome analyses of dividing cells in the host lymphoid and myeloid organs were performed at intervals after irradiation. Donor marrow cells settled and proliferated in the host bone marrow, spleen, and lymph nodes soon after injection, but donor marrow cells did not proliferate in the host thymus until day 10; then host-type cells were quickly replaced by donor-type cells in the thymus by day 20. On the other hand, donor thymus cells settled and proliferated in the host thymus and lymph nodes soon after injection but they gradually disappeared from these organs. On day 20, a few donor-type dividing cells (of thymus origin) were found in the host lymphoid and myeloid organs.

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References

    1. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71 - PubMed
    1. J Immunol. 1966 Dec;97(6):828-32 - PubMed
    1. J Exp Med. 1968 Oct 1;128(4):821-37 - PubMed
    1. J Exp Med. 1969 Mar 1;129(3):445-57 - PubMed
    1. Transplantation. 1971 Oct;12(4):334-8 - PubMed