Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Aug;8(2):278-90.
doi: 10.1128/iai.8.2.278-290.1973.

Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation

A L Smith, D H Smith, D R Averill Jr, J Marino, E R Moxon

Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation

A L Smith et al. Infect Immun. 1973 Aug.

Abstract

Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.

PubMed Disclaimer

References

    1. J Neuropathol Exp Neurol. 1960 Apr;19:248-65 - PubMed
    1. J Biol Chem. 1958 Jul;233(1):184-8 - PubMed
    1. J Clin Invest. 1972 Jan;51(1):31-8 - PubMed
    1. Adv Pediatr. 1964;13:129-81 - PubMed
    1. N Engl J Med. 1965 Apr 15;272:779-87 CONTD - PubMed

LinkOut - more resources