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. 1973 Dec;52(12):3239-42.
doi: 10.1172/JCI107525.

Human lymphocytes bear membrane receptors for C3b and C3d

A Eden, G W Miller, V Nussenzweig

Human lymphocytes bear membrane receptors for C3b and C3d

A Eden et al. J Clin Invest. 1973 Dec.

Abstract

Human peripheral blood lymphocytes have membrane receptors for EAC43b (sheep erythrocytes sensitized with antibody and complement) and also for EAC43d, obtained by treating EAC43b with C3b inactivator. Human granulocytes bind only EAC43b, C3 fragments obtained by limited trypsin digestion of purified human C3 display both C3b and C3d sites, since they inhibit rosette formation of lymphocytes with EAC43b and EAC43d. These findings raise the possibility that C3b and C3d receptor sites may be selectively distributed among normal subpopulations of B lymphocytes as well as among leukemic leukocytes.

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References

    1. J Immunol. 1967 Aug;99(2):263-8 - PubMed
    1. J Immunol. 1967 Sep;99(3):582-9 - PubMed
    1. J Immunol. 1968 Apr;100(4):691-8 - PubMed
    1. Exp Cell Res. 1968 Jul;51(1):45-67 - PubMed
    1. J Exp Med. 1969 Jan 1;129(1):167-84 - PubMed

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