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. 1974 Mar 1;139(3):754-60.
doi: 10.1084/jem.139.3.754.

Autoradiographic studies on the proliferation of antibody-producing cells in vitro

T Hünig, A Schimpl, E Wecker

Autoradiographic studies on the proliferation of antibody-producing cells in vitro

T Hünig et al. J Exp Med. .

Abstract

A rapid and reliable autoradiographic technique for plaque-forming cells (PFCs) using (14)C rather than tritiated thymidine is described. Its application to PFCs developing in vitro shows that (a) practically all PFCs derive from precursors dividing steadily during the culture period, (b) PFC precursors divide in the absence of T-cell helper function, and (c) at least some PFCs may continue to divide.

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