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. 1974 Mar 1;139(3):779-84.
doi: 10.1084/jem.139.3.779.

Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect

F Y Liew, C R Parish

Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect

F Y Liew et al. J Exp Med. .

Abstract

The relationship between cell-mediated immunity to the carrier and the carrier-hapten helper effect was studied in the rat by using three forms of the carrier which differed in their capacity to induce carrier-specific delayed-type hypersensitivity. The three carriers were polymerized flagellin (POL), flagellin (FIN), and acetoacetylated flagellin (AFIN), which induced FIN-specific delayed-type hypersensitivity in the order AFIN > FIN > POL. Helper cells for the anti-DNP antibody responses to a range of DNP-FIN conjugates appeared to be almost inversely related to cell-mediated immunity to the carrier, being in the order POL > FIN =/> AFIN. These differences occurred whether the carriers were injected in saline or FCA, but were less pronounced with the heavily DNP-conjugated flagellins.

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