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. 1974 Apr;71(4):1474-8.
doi: 10.1073/pnas.71.4.1474.

Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus

R S Basch, G Goldstein

Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus

R S Basch et al. Proc Natl Acad Sci U S A. 1974 Apr.

Abstract

Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (theta) antigens than average normal thymocytes.

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