The cellular origin of the lymphochte trap

Abstract

We investigated the cellular requirements for lymphocyte trapping. Depletion of lymphocyte populations selectively or indiscriminately did not affect the ability of animals to trap. The variety of materials which initiate trapping was also studied and this information, coupled with the resistance of `trapping' to severe lymphocyte depletion, is consistent with the hypothesis that the macrophage may be the central cell in initiating the trapping of lymphocytes after antigen stimulation.