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. 1974 Apr;27(4):326-9.
doi: 10.1136/jcp.27.4.326.

The effect of age on the fibrinolytic enzyme system

P J Hamilton, A A Dawson, D Ogston, A S Douglas

The effect of age on the fibrinolytic enzyme system

P J Hamilton et al. J Clin Pathol. 1974 Apr.

Abstract

Components of the fibrinolytic enzyme system, FR-antigen and fibrinogen, were measured in 20 healthy volunteers aged 20-40 years and in 61 elderly subjects aged 66-96 years. Plasminogen activator levels did not significantly differ between the 20-40 and 66-75 age groups, but were higher in those over 75. Plasminogen showed no change with age except for a fall in those over 75. Fibrinogen, FR-antigen, alpha(1)-antitrypsin, and alpha(2)-macroglobulin all rose with age, but the mean fibrinogen concentration fell in the very elderly.

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