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. 1974 Dec;6(6):869-70.
doi: 10.1128/AAC.6.6.869.

In vitro susceptibility of Haemophilus influenzae to trimethoprim-sulfamethoxazole

L A Kirven, C Thornsberry

In vitro susceptibility of Haemophilus influenzae to trimethoprim-sulfamethoxazole

L A Kirven et al. Antimicrob Agents Chemother. 1974 Dec.

Abstract

Thirty-four strains of Haemophilus influenzae (20 ampicillin sensitive and 14 ampicillin resistant), mostly type b isolates from cerebrospinal fluid or blood, were tested for susceptibility to a combination of trimethoprim-sulfamethoxazole (TMP-SMZ) in a ratio of 1 part TMP to 19 parts SMZ. All strains were very susceptible to the TMP-SMZ combination, with minimal inhibitory concentrations ranging from 0.007-0.14 to 0.06-1.18 mug of TMP-SMZ per ml. There was little difference in the susceptibility of the ampicillin-sensitive and ampicillin-resistant strains to TMP-SMZ.

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