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. 1974 Jun;50(584):362-4.
doi: 10.1136/pgmj.50.584.362.

Genetic aspects of the Pi system

P J Cook

Genetic aspects of the Pi system

P J Cook. Postgrad Med J. 1974 Jun.

Abstract

α1-Antitrypsin can be shown to be polymorphic by starch gel electrophoresis. At present 19 different alleles are known which are inherited in an autosomal pattern and constitute the Pi system. In one phenotype called Pi type ZZ there is a virtual deficiency of plasma α1-antitrypsin and about 230 such babies are expected in England and Wales every year.

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References

    1. Science. 1965 Aug 27;149(3687):986-7 - PubMed
    1. Br J Dis Chest. 1973 Jul;67(3):171-96 - PubMed
    1. Ann Hum Genet. 1972 Apr;35(4):393-9 - PubMed

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