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. 1972 Mar;69(3):608-12.
doi: 10.1073/pnas.69.3.608.

Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A

I Yahara, G M Edelman

Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A

I Yahara et al. Proc Natl Acad Sci U S A. 1972 Mar.

Abstract

The induction by anti-immunoglobulin of patch and cap formation on mouse lymphocytes was inhibited by the addition of concanavalin A. This effect was reversed by alpha-methyl-D-mannoside, a competitive inhibitor of the binding of concanavalin A. Concanavalin A prevented both patch and cap formation, in contrast to the metabolic inhibitor NaN(3), which prevented only cap formation. This suggests that binding of concanavalin A induces changes on or in the lymphocyte membrane that inhibit free diffusion of immunoglobulin receptors.

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References

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