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. 1979 May;6(6):331-5.
doi: 10.1016/s0304-3835(79)80090-7.

Photodynamic inactivation of cancer cells in vitro. Effect of irradiation temperature and dose fractionation

J Moan, T Christensen

Photodynamic inactivation of cancer cells in vitro. Effect of irradiation temperature and dose fractionation

J Moan et al. Cancer Lett. 1979 May.

Abstract

Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient when it is fractionated than when it is given in a single exposire. These findings may be taken advantage of in future photochemotherapy of cancer.

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