Reduction of the renal toxicity of cis-dichlorodiammineplatinum(II) by probenecid
- PMID: 455315
Item in Clipboard
Reduction of the renal toxicity of cis-dichlorodiammineplatinum(II) by probenecid
Cancer Treat Rep.
1979 May.
Abstract
Probenecid, when administered sc to F344 rats 1 hour prior to an iv LD50 dose of cis-dichlorodiammineplatinum(II) (CDPP), reduced significantly the peak BUN and serum creatinine levels which occurred 4 days following CDDP. Renal histopathology was similarly reduced by probenecid pretreatment. In BDF, mice, the LD50 value of CDDP administered ip without probenecid pretreatment was 17 mg/kg; the LD50 dose with probenecid was increased to greater than 19 mg/kg. Probenecid pretreatment did not influence the therapeutic response to CDDP when the letter was administered to BDF mice bearing L1210 leukemia.
Similar articles
-
cis-Dichlorodiammineplatinum nephrotoxicity in rats of different ages.Res Commun Chem Pathol Pharmacol. 1984 May;44(2):279-91. Res Commun Chem Pathol Pharmacol. 1984. PMID: 6539942
-
Methimazole protection of rats against chemically induced kidney damage in vivo.J Pharmacol Exp Ther. 1992 Jan;260(1):393-401. J Pharmacol Exp Ther. 1992. PMID: 1731048
-
Amelioration of cisplatin-induced nephrotoxicity by the diuretic acetazolamide in F344 rats.Cancer Treat Rep. 1984 Jul-Aug;68(7-8):999-1004. Cancer Treat Rep. 1984. PMID: 6540145
-
Antileukemia (L1210) activity and toxicity of cis-dichlorodiammineplatinum(II) analogs.Cancer Treat Rep. 1979 Sep-Oct;63(9-10):1503-8. Cancer Treat Rep. 1979. PMID: 498150
-
[Prophylactic effect of methylprednisolone on cisplatin-induced nephrotoxicity in rats].Gan To Kagaku Ryoho. 1993 Aug;20(10):1363-7. Gan To Kagaku Ryoho. 1993. PMID: 8346934 Japanese.
Cited by
-
Renal elimination of the hypoxic cell radiosensitizer misonidazole in Wistar rats: influence of some drugs on its excretion.Eur J Drug Metab Pharmacokinet. 1985 Jul-Sep;10(3):181-7. doi: 10.1007/BF03189740. Eur J Drug Metab Pharmacokinet. 1985. PMID: 4085520
-
The nephrotoxic potential of drugs and chemicals. Pharmacological basis and clinical relevance.Med Toxicol Adverse Drug Exp. 1989 Jan-Feb;4(1):59-72. doi: 10.1007/BF03259903. Med Toxicol Adverse Drug Exp. 1989. PMID: 2651851 Review.
-
Cisplatin-induced renal injury is independently mediated by OCT2 and p53.Clin Cancer Res. 2014 Aug 1;20(15):4026-35. doi: 10.1158/1078-0432.CCR-14-0319. Epub 2014 Jun 10. Clin Cancer Res. 2014. PMID: 24916697 Free PMC article.
-
Hyperuricemia and hypoalbuminemia predispose to cisplatin-induced nephrotoxicity.Cancer Chemother Pharmacol. 1986;17(3):274-6. doi: 10.1007/BF00256698. Cancer Chemother Pharmacol. 1986. PMID: 3742714
-
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.Cancer Chemother Pharmacol. 1986;18(3):231-4. doi: 10.1007/BF00273392. Cancer Chemother Pharmacol. 1986. PMID: 3802378