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. 1979;64(1):129-31.
doi: 10.1016/0305-0491(79)90197-4.

NAD-linked glutamate dehydrogenase in Trypanosoma cruzi

J J Cazzulo  1 , B M de Cazzulo, A I Higa, E L Segura
Affiliations

NAD-linked glutamate dehydrogenase in Trypanosoma cruzi

J J Cazzulo et al. Comp Biochem Physiol B. 1979.

Abstract

1. Epimastigotes of Trypanosoma cruzi, Tulahuén strain, contained a NAD-linked glutamate dehydrogenase (EC 1.4.1.3), in addition to the already known NADP-linked enzyme enzyme (EC 1.4.1.4). 2. The partially purified NAD-linked enzyme had a higher molecular weight and was much more labile than the NADP-linked enzyme, and was inhibited by purine nucleotides. 3. These results further emphasize the difference in glutamate metabolism between the parasite and its mammalian host.

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