Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Jun;11(2):265-76.

Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA)

J H ten Veen, T E Feltkamp

Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA)

J H ten Veen et al. Clin Exp Immunol. 1972 Jun.

Abstract

Hydralazin, isoniazid, procainamide, α-methyldopa and chlorthalidone were given orally to mice of three inbred strains: BALB/CJ, C57/BL/6J and A/JAX. All drugs significantly increased the frequency of antinuclear antibodies (ANA). The results were most marked after 8 months of treatment. Although a slight preponderance of females was observed for ANA frequencies in BALB/CJ and A/JAX mice, this was significant only for hydralazin- and procainamide-treated animals. C57/BL/6J males appeared to respond better than females. Genetical factors appear of importance in the induciton of drug induced lupus erythematosus (DILE).

PubMed Disclaimer

References

    1. N Engl J Med. 1965 Mar 4;272:462-6 - PubMed
    1. S Afr Med J. 1968 Aug 17;42(32):826-8 - PubMed
    1. Science. 1969 Dec 26;166(3913):1648-9 - PubMed
    1. Clin Exp Immunol. 1969 Oct;5(4):429-37 - PubMed
    1. Acta Med Scand. 1970 Mar 3;187(3):219-23 - PubMed

LinkOut - more resources