Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Aug;69(8):2061-5.
doi: 10.1073/pnas.69.8.2061.

The stabilization of episomal integration by genetic inversion: a general hypothesis

E A Adelberg, P Bergquist

The stabilization of episomal integration by genetic inversion: a general hypothesis

E A Adelberg et al. Proc Natl Acad Sci U S A. 1972 Aug.

Abstract

In F' cells of Escherichia coli K12, recombination in the region of genetic duplication between chromosome and F-genote produces a rapid alteration between the integrated and detached states of the episome. Nevertheless, F' strains can give rise to Hfr cells in which the F-genote has undergone stable integration. We have found that one such Hfr has retained the genetic duplication as well as the recombination proficiency of the parental F' strain; to account for the failure of recombination to detach the episome in this Hfr, we have postulated the inversion of one of the duplicated regions. A general model is presented, showing that an inversion must prevent episome detachment by any combination of genetic crossovers.

PubMed Disclaimer

References

    1. Genetics. 1966 Jun;53(6):1137-50 - PubMed
    1. Genetics. 1967 Jul;56(3):503-25 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1966;31:393-401 - PubMed
    1. Bacteriol Rev. 1970 Jun;34(2):155-75 - PubMed
    1. Bacteriol Rev. 1970 Jun;34(2):176-93 - PubMed

LinkOut - more resources