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. 1972 Oct 1;136(4):663-75.
doi: 10.1084/jem.136.4.663.

Surface antigens of immunocompetent cells. 3. In vitro studies of the role of B and T cells in immunological memory

J J Mond, T Takahashi, G J Thorbecke

Surface antigens of immunocompetent cells. 3. In vitro studies of the role of B and T cells in immunological memory

J J Mond et al. J Exp Med. .

Abstract

The effect of preincubation with anti-theta or anti-mouse immunoglobulin (Ig) and complement (C') on immune responsiveness of spleen cells from BALB/c mice immunized with sheep erythrocytes (SE) was investigated. Both treatments greatly depressed the remaining ability to produce a secondary response to SE in vitro. Normal BALB/c spleen cells were far less effective in reconstituting the responses of such depleted cell populations than were much smaller numbers of untreated immune spleen cells. Thymus-derived cell (T cell) memory appeared early after immunization and showed specificity for the immunizing antigens. Recombination of anti-Ig-treated with anti-theta-treated immune spleen cells resulted in virtually complete reconstitution of responsiveness. The presence of immunological memory in T cells and the nature of their surface receptors are discussed.

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