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. 1979 Mar;24(3):217-20.
doi: 10.1007/BF01308433.

Nonsteroidal antiinflammatory drugs: effect on pyloric sphincter and duodenogastric reflux

J L Pantoja, C Defilippi, J E Valenzuela, A Csendes

Nonsteroidal antiinflammatory drugs: effect on pyloric sphincter and duodenogastric reflux

J L Pantoja et al. Dig Dis Sci. 1979 Mar.

Abstract

We have investigated the effect of nonsteroidal antiinflammatory drugs on canine pyloric sphincter pressure, mucosal potential difference (PD), and duodenogastric reflux in 5 dogs. Only intragastric aspirin at doses of 30 and 100 mg/kg caused a significant (P less than 0.05) decrease in pyloric sphincter pressure, an increase of duodenogastric reflux, and changed the mucosal PD. Neither intravenous aspirin, intragastric phenylbutazone, or intrarectal indomethacin produced these changes. The mechanism for the aspirin effect may be mediated by local pathways related to changes in mucosal PD. We postulate that increased duodenogastric reflux may be an aggravating factor for the gastric mucosal damage caused by intragastric aspirin.

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