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. 1972 Oct;69(10):2818-22.
doi: 10.1073/pnas.69.10.2818.

Transcription in yeast: a factor that stimulates yeast RNA polymerases

E Di Mauro, C P Hollenberg, B D Hall

Transcription in yeast: a factor that stimulates yeast RNA polymerases

E Di Mauro et al. Proc Natl Acad Sci U S A. 1972 Oct.

Abstract

Yeast cells contain an RNA polymerase factor, pi, which is a heat-stable protein with an apparent molecular weight of 12,000. This factor stimulates transcription of calf-thymus, salmon-sperm, yeast-nuclear, and T4-phage DNA. It stimulates transcription by each of the four yeast-nuclear RNA polymerases, by rat-liver RNA polymerases I and II, and by Escherichia coli RNA polymerase. pi-Factor can cause each of the eukaryotic RNA polymerases to become insensitive to rifamycin AF-013, but does not stop inhibition of E. coli RNA polymerase by rifamycin AF-013. Stimulation of transcription by pi-factor is general, and does not apply only to a limited class of genes. Apparently, pi-factor stimulates transcription by increasing the proportion of RNA polymerase binding events that leads to the initiation of RNA chains.

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References

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