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Clinical Trial
. 1972 Oct;35(5):599-605.
doi: 10.1136/jnnp.35.5.599.

Assessment of cyclobenzaprine in the treatment of spasticity

P Ashby, D Burke, S Rao, R F Jones
Clinical Trial

Assessment of cyclobenzaprine in the treatment of spasticity

P Ashby et al. J Neurol Neurosurg Psychiatry. 1972 Oct.

Abstract

The efficacy of cyclobenzaprine 60 mg/day in the treatment of spasticity was assessed in a double-blind crossover trial of two weeks' duration in 15 patients suffering from cerebral or spinal spasticity. Independent clinical and electromyographic methods were used. The effects of cyclobenzaprine did not differ significantly from those of placebo. The administration of a higher dosage, 150 mg/day, to one patient revealed a dose-related response, but the degree of improvement was clinically small. Apart from a skin rash there were no significant untoward effects of therapy.

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References

    1. J Neurol Neurosurg Psychiatry. 1970 Apr;33(2):216-23 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):464-8 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1971 Jun;34(3):231-5 - PubMed
    1. J Neurol Sci. 1971 Oct;14(2):199-208 - PubMed

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