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. 1972 Nov 24;178(4063):875-6.
doi: 10.1126/science.178.4063.875.

Primary structure of neocarzinostatin, an antitumor protein

J Meienhofer, H Maeda, C B Glaser, J Czombos, K Kuromizu

Primary structure of neocarzinostatin, an antitumor protein

J Meienhofer et al. Science. .

Abstract

The antitumor protein neocarzinostatin is an acidic single-chain molecule, cross-linked by two disulfide bridges, and consists of 109 amino acid residues. Complete disulfide bond reduction and S-carboxymethylation was achieved in liquid ammonia. Sequence determination of five tryptic fragments led to the proposed primary structure.

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