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. 1972 Nov;69(11):3138-41.
doi: 10.1073/pnas.69.11.3138.

DNA modification methylase activity of Escherichia coli restriction endonucleases K and P

A Haberman, J Heywood, M Meselson

DNA modification methylase activity of Escherichia coli restriction endonucleases K and P

A Haberman et al. Proc Natl Acad Sci U S A. 1972 Nov.

Abstract

The highly purified restriction endonucleases of E. coli K and coliphage P1 transfer methyl groups from S-adenosylmethionine to adenine residues of unmodified DNA. Incubation of unmodified DNA with endonucleases K or P and S-adenosylmethionine renders the DNA resistant to restriction. The enzymes, therefore, have both restriction endonuclease and modification methylase activities.

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References

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