Human diseases associated with mycoplasms. With an appendix on simple culture techniques

Abstract

The mycoplasmas (formerly called pleuropneumonia-like organisms, or pplo) are a group of pleomorphic micro-organisms characterized by lack of cell wall and ability to form colonies on agar resembling tiny fried eggs. They have been recognized as pathogens of lower mammals since 1898. Of the more than 40 known veterinary species, many are pathogens, commonly causing pneumonia, arthritis or arteritis. Of the mycoplasmas found in man, Mycoplasma pneumoniae is the only well established human pathogen. It is responsible for a variety of respiratory syndromes, of which the most frequently recognized is cold agglutinin-positive atypical pneumonia. Hematologic, neurologic and dermatologic complications of this infection have been noted. M. hominis has been implicated as a causative factor in various febrile complications of pregnancy, such as septic abortion and amnionitis. T-strain mycoplasmas are ubiquitous in the human genitourinary tract, but attempts to link their presence to disease have thus far been unsuccessful. Mycoplasmas also have been associated with neoplastic disease and with rheumatoid arthritis. The validity of these latter findings is unclear, and additional study is needed.