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. 1973 Feb;70(2):253-72.

Chylomicrons and the formation of foam cells in type I hyperlipoproteinemia. A morphologic study

V J Ferrans, W C Roberts, R I Levy, D S Fredrickson

Chylomicrons and the formation of foam cells in type I hyperlipoproteinemia. A morphologic study

V J Ferrans et al. Am J Pathol. 1973 Feb.

Abstract

Light and electron microscopic study of aspirated bone marrow of a patient with type I hyperlipoproteinemia disclosed large, birefringent foam cells which develop from phagocytosis of chylomicrons by histiocytes. Chylomicrons are taken up, singly and in aggregates, by infoldings of the plasma membranes of histiocytes; these infoldings become phagocytic vacuoles within the cytoplasm. As chylomicrons are metabolized, the foam cells decrease in size, lose birefringence and develop autofluorescent, electron-dense deposits of ceroid.

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