doi: 10.1084/jem.137.2.547.
Stimulation of IgG antibody response in vitro by T cell-replacing factor
- PMID: 4568302
- PMCID: PMC2139499
- DOI: 10.1084/jem.137.2.547
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Stimulation of IgG antibody response in vitro by T cell-replacing factor
J Exp Med.
.
Abstract
A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.
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