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. 1973 Feb 1;137(2):547-52.
doi: 10.1084/jem.137.2.547.

Stimulation of IgG antibody response in vitro by T cell-replacing factor

A Schimpl, E Wecker

Stimulation of IgG antibody response in vitro by T cell-replacing factor

A Schimpl et al. J Exp Med. .

Abstract

A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.

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