Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Mar;113(3):1091-5.
doi: 10.1128/jb.113.3.1091-1095.1973.

Close linkage of the genes serC (for phosphohydroxy pyruvate transaminase) and serS (for seryl-transfer ribonucleic acid synthetase) in Escherichia coli K-12

S J Clarke, B Low, W H Konigsberg

Close linkage of the genes serC (for phosphohydroxy pyruvate transaminase) and serS (for seryl-transfer ribonucleic acid synthetase) in Escherichia coli K-12

S J Clarke et al. J Bacteriol. 1973 Mar.

Abstract

Escherichia coli strain K28, isolated after nitrosoguanidine mutagenesis, was found to be auxotrophic for serine. It was also temperature sensitive for growth as a result of producing an altered seryl-transfer ribonucleic acid (tRNA) synthetase (EC 6.1.1.11, l-serine: tRNA ligase [AMP]). The auxotrophy was caused by a mutation in the structural gene for phosphohydroxy-pyruvate transaminase (serC), which was distinct from, but closely linked to, the structural gene for seryl-tRNA synthetase (serS). We conclude that the relevant genes are in the order gal-serS-serC-aroA.

PubMed Disclaimer

References

    1. Bacteriol Rev. 1966 Dec;30(4):701-19 - PubMed
    1. J Bacteriol. 1968 Apr;95(4):1283-94 - PubMed
    1. Mol Gen Genet. 1968;102(1):15-26 - PubMed
    1. J Bacteriol. 1969 Oct;100(1):167-75 - PubMed
    1. J Bacteriol. 1969 Nov;100(2):1114-5 - PubMed

MeSH terms

LinkOut - more resources