doi: 10.1016/s0304-3835(77)80024-4.
Blastogenic response and EBNA induction in human lymphocytes by Epstein-Barr virus only requires B cells but not macrophages
Affiliations
- PMID: 45722
- DOI: 10.1016/s0304-3835(77)80024-4
Item in Clipboard
Blastogenic response and EBNA induction in human lymphocytes by Epstein-Barr virus only requires B cells but not macrophages
Cancer Lett.
1977 Mar.
Abstract
The postulated role of macrophages in the primary infection of human lymphocytes by Epstein-Barr virus (EBV) was examined. Macrophage removal had no effect on the blastogenic response but slightly reduced the percentage of EBNA-positive cells induced by the B 95-8 virus strain. Both the rate of DNA synthesis and the appearance of EBNA-positive cells could rather be related to the number of B cells in the infected populations. Macrophages are thus not required for the initiation of EBV-induced lymphocyte transformation.
Similar articles
-
Epstein-Barr virus susceptibility of normal human B lymphocyte populations.J Exp Med. 1984 Jan 1;159(1):208-20. doi: 10.1084/jem.159.1.208. J Exp Med. 1984. PMID: 6319530 Free PMC article.
-
Epstein-Barr virus (EBV) nuclear antigen 6 induces expression of the EBV latent membrane protein and an activated phenotype in Raji cells.J Gen Virol. 1993 Mar;74 ( Pt 3):361-9. doi: 10.1099/0022-1317-74-3-361. J Gen Virol. 1993. PMID: 8383171
-
A subpopulation of normal B cells latently infected with Epstein-Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1.J Virol. 1995 Jun;69(6):3752-8. doi: 10.1128/JVI.69.6.3752-3758.1995. J Virol. 1995. PMID: 7745723 Free PMC article.
-
The changing faces of EBV research.Prog Med Virol. 1984;30:87-106. Prog Med Virol. 1984. PMID: 6087416 Review. No abstract available.
-
Role of EBV and Ig/myc translocation in Burkitt lymphoma.Antibiot Chemother (1971). 1994;46:110-6. doi: 10.1159/000423638. Antibiot Chemother (1971). 1994. PMID: 7826031 Review. No abstract available.
Cited by
-
Short-term assays for mesenchymal stromal cell immunosuppression of T-lymphocytes.Front Immunol. 2023 Sep 26;14:1225047. doi: 10.3389/fimmu.2023.1225047. eCollection 2023. Front Immunol. 2023. PMID: 37822938 Free PMC article.
-
Blastogenic response of purified human T-lymphocyte populations to Epstein-Barr virus (EBV).Clin Exp Immunol. 1977 Dec;30(3):347-53. Clin Exp Immunol. 1977. PMID: 203426 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
