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Comparative Study
. 1977 Mar;2(4-5):239-46.
doi: 10.1016/s0304-3835(77)80028-1.

The deficiency of cyclic AMP responsive G1 controls in cultured malignant liver epithelial cells

G M Williams  1
Affiliations
Comparative Study

The deficiency of cyclic AMP responsive G1 controls in cultured malignant liver epithelial cells

G M Williams. Cancer Lett. 1977 Mar.

Abstract

Normal rat liver epithelial cells in culture were blocked outside the S phase by dibutyryl cyclic AMP while malignant rat liver epithelial cells were slowed in S phase. It is suggested that this lack of normal response to a growth inhibitory factor by malignant cells may underly their relatively autonomous growth behavior.

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