doi: 10.1093/infdis/133.5.564.
Further observations on the potentiation of the antibacterial effect of methenamine by acetohydroxamic acid
- PMID: 4573
- DOI: 10.1093/infdis/133.5.564
Item in Clipboard
Further observations on the potentiation of the antibacterial effect of methenamine by acetohydroxamic acid
J Infect Dis.
1976 May.
Abstract
The use of methenamine in the treatment of urinary tract infections due to Proteus species is limited by urine alkalinity. Acetohydroxamic acid, an inhibitor of urease, maintains acidity despite growth of Proteus in urine. Easily achievable concentrations of acetohydroxamic acid in vitro systems that simulated the dynamics of the urinary tract potentiated the antibacterial effect of methenamine against Proteus species. The combined use of a urease inhibitor and methenamine may be effective in the treatment of urinary infection caused by these organisms.
Similar articles
-
Potentiation of the antibacterial effect of methenamine by acetohydroxamic acid.Antimicrob Agents Chemother. 1974 Feb;5(2):101-5. doi: 10.1128/AAC.5.2.101. Antimicrob Agents Chemother. 1974. PMID: 4840424 Free PMC article.
-
Role of urease in pyelonephritis resulting from urinary tract infection with Proteus.J Infect Dis. 1975 Feb;131(2):177-81. doi: 10.1093/infdis/131.2.177. J Infect Dis. 1975. PMID: 234993
-
The effect of acetohydroxamic acid on the induction of bacterial ureases.Invest Urol. 1980 Sep;18(2):112-4. Invest Urol. 1980. PMID: 6997229
-
Drug therapy reviews: methenamine mandelate and methenamine hippurate.Am J Hosp Pharm. 1979 Nov;36(11):1509-12. Am J Hosp Pharm. 1979. PMID: 391033 Review.
-
[Urinary calculi and infection].Urologia. 2014 Apr-Jun;81(2):93-8. doi: 10.5301/uro.5000073. Epub 2014 May 27. Urologia. 2014. PMID: 24874306 Review. Italian.
Cited by
-
Interaction of polymorphonuclear neutrophils with Escherichia coli. Effect of enterotoxin on phagocytosis, killing, chemotaxis, and cyclic AMP.J Clin Invest. 1978 Feb;61(2):227-34. doi: 10.1172/JCI108931. J Clin Invest. 1978. PMID: 202610 Free PMC article.
-
Membrane receptors for bacterial toxins.Microbiol Rev. 1983 Dec;47(4):596-620. doi: 10.1128/mr.47.4.596-620.1983. Microbiol Rev. 1983. PMID: 6363900 Free PMC article. Review. No abstract available.
-
Comparison of effects of nicked and unnicked Escherichia coli heat-labile enterotoxin on Chinese hamster ovary cells.Infect Immun. 1984 Oct;46(1):94-7. doi: 10.1128/iai.46.1.94-97.1984. Infect Immun. 1984. PMID: 6384049 Free PMC article.
-
Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells.Microbiol Rev. 1978 Sep;42(3):592-613. doi: 10.1128/mr.42.3.592-613.1978. Microbiol Rev. 1978. PMID: 82199 Free PMC article. Review. No abstract available.
-
5-Hydroxytryptamine and cholera secretion: a histochemical and physiological study in cats.Gut. 1983 Jun;24(6):542-8. doi: 10.1136/gut.24.6.542. Gut. 1983. PMID: 6852634 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
