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. 1973 May 11;180(4086):647-9.
doi: 10.1126/science.180.4086.647.

Pronase effect on pancreatic beta cell secretion and morphology

L Orci, M Amherdt, J C Henquin, A E Lambert, R H Unger, A E Renold

Pronase effect on pancreatic beta cell secretion and morphology

L Orci et al. Science. .

Abstract

Pronase at low concentration (4 micrograms per milliliter) produces a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.

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