Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 May 1;137(5):1142-62.
doi: 10.1084/jem.137.5.1142.

Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution

R M Steinman, Z A Cohn

Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution

R M Steinman et al. J Exp Med. .

Abstract

A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1-1.6% of the total nucleated cells) the cells have distinct morphological features. The nucleus is large, retractile, contorted in shape, and contains small nucleoli (usually two). The abundant cytoplasm is arranged in processes of varying length and width and contains many large spherical mitochondria. In the living state, the cells undergo characteristic movements, and unlike macrophages, do not appear to engage in active endocytosis. The term, dendritic cell, is proposed for this novel cell type.

PubMed Disclaimer

Comment in

References

    1. J Exp Med. 1966 Jan 1;123(1):145-60 - PubMed
    1. J Exp Med. 1966 Oct 1;124(4):557-71 - PubMed
    1. J Histochem Cytochem. 1966 Apr;14(4):291-302 - PubMed
    1. Science. 1967 Dec 22;158(3808):1573-5 - PubMed
    1. J Exp Med. 1968 Feb 1;127(2):277-90 - PubMed