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Review
. 1973:24:1-18.
doi: 10.1146/annurev.me.24.020173.000245.

Platelet function tests in disease

T B Tschopp, M B Zucker
Review

Platelet function tests in disease

T B Tschopp et al. Annu Rev Med. 1973.

Abstract

PIP: Abnormal platelet function may result from congenital or acquired disturbances in the platelets themselves or their plasma milieu in patients with hemorrhage or thrombosis. Although standardization is difficult and results overlap between patient groups, certain tests are abnormal in patients with diabetes and atherosclorosis, and in women on oral contraceptives, all of whom have an increased tendency toward thrombosis. In women on oral contraceptive pills containing synthetic estrogen and progesterone, fibrin formation starts earlier and develops more rapidly when assessed by the thrombelastograph, and as in late pregnancy, Factors VII and X are increased. Most studies did not report an increase in platelet adhesiveness or in platelet retention measured in whole citrated blood. An increase in platelet sensitivity to ADP, as measured by electropheretic mobility was observed in 1 study.

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