Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 May;70(5):1564-8.
doi: 10.1073/pnas.70.5.1564.

Synthesis of guanosine tetra- and pentaphosphate requires the presence of a codon-specific, uncharged transfer ribonucleic acid in the acceptor site of ribosomes

W A Haseltine, R Block

Synthesis of guanosine tetra- and pentaphosphate requires the presence of a codon-specific, uncharged transfer ribonucleic acid in the acceptor site of ribosomes

W A Haseltine et al. Proc Natl Acad Sci U S A. 1973 May.

Abstract

The nucleotides ppGpp and pppGpp accumulate when wild-type, but not rel(-), strains of Escherichia coli are starved for required amino acids. These compounds are synthesized on ribosomes, in the presence of the product of the rel gene, from GDP and GTP; ATP is used as the phosphate donor. The signal for making these compounds is the presence of an uncharged tRNA in the ribosomal acceptor site. These compounds are not accumulated if the ribosomes are actively engaged in protein synthesis.

PubMed Disclaimer

References

    1. Bacteriol Rev. 1966 Dec;30(4):701-19 - PubMed
    1. J Mol Biol. 1967 Sep 14;28(2):311-30 - PubMed
    1. Biochemistry. 1968 Oct;7(10):3459-68 - PubMed
    1. Bacteriol Rev. 1968 Sep;32(3):206-26 - PubMed
    1. Nature. 1969 Mar 1;221(5183):838-41 - PubMed

MeSH terms

LinkOut - more resources