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. 1973 Jun;11(6):879-85.
doi: 10.1128/JVI.11.6.879-885.1973.

Prophage induction by high temperature in thermosensitive dna mutants lysogenic for bacteriophage lambda

H Schuster, D Beyersmann, M Mikolajczyk, M Schlicht

Prophage induction by high temperature in thermosensitive dna mutants lysogenic for bacteriophage lambda

H Schuster et al. J Virol. 1973 Jun.

Abstract

High-temperature treatment of thermosensitive dna mutants lysogenic for phage lambda leads to prophage induction and release of phage (at the permissive temperature) in elongation-defective mutants of the genotypes dnaB, dnaE, and dnaG. In initiation-defective mutants no prophage induction occurs at 42 C in mutants of the genotype dnaA, whereas with a dnaC mutant as well as with strain HfrH 252 (map position not yet known) phages are released at 42 C. DNA degradation at the replication fork at 42 C is observed in all dnaB(lambda) mutants tested, but not in mutants of the genotypes dnaE(lambda) and dnaG(lambda). Therefore, degradation of replication fork DNA is not a prerequisite for prophage induction.

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