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. 1973 Jun 2;2(5865):520-3.
doi: 10.1136/bmj.2.5865.520.

Effect of copper-containing intrauterine contraceptive devices on human cells in culture

R W Jones, N M Gregson, M Elstein

Effect of copper-containing intrauterine contraceptive devices on human cells in culture

R W Jones et al. Br Med J. .

Abstract

Intrauterine devices containing copper were introduced into cultures of adult and fetal cells. The Dalkon shield had no apparent effect on cell growth. The Gravigard device caused inhibition of growth and an increase in copper concentration in the supranatant medium. When the latter device was transferred through a series of subcultures the rate of release of copper decreased and growth was no longer inhibited.

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References

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