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. 1973 Mar;70(3):934-8.
doi: 10.1073/pnas.70.3.934.

An RNA that multiplies indefinitely with DNA-dependent RNA polymerase: selection from a random copolymer

C K Biebricher, L E Orgel

An RNA that multiplies indefinitely with DNA-dependent RNA polymerase: selection from a random copolymer

C K Biebricher et al. Proc Natl Acad Sci U S A. 1973 Mar.

Abstract

We have selected from a mixture of random polynucleotides an RNA that is able to replicate in the presence of the DNA-dependent RNA polymerase of Escherichia coli, provided the medium contains Mn(2+) and ITP, in addition to ATP, CTP, and UTP. The RNA consists of a chain of about 125 (+/-25) nucleotides and appears to have a defined, nonrepetitive sequence.

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References

    1. Proc Natl Acad Sci U S A. 1967 Jul;58(1):217-24 - PubMed
    1. Biochem Biophys Res Commun. 1967 Mar 21;26(6):639-44 - PubMed
    1. J Biol Chem. 1968 May 25;243(10):2769-78 - PubMed
    1. J Biol Chem. 1969 Nov 25;244(22):6160-7 - PubMed
    1. J Mol Biol. 1969 Oct 28;45(2):181-93 - PubMed

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