Review
doi: 10.3109/09687687809063855.
Proposed knobs-into-holes packing for several membrane proteins
Affiliations
- PMID: 45776
- DOI: 10.3109/09687687809063855
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Review
Proposed knobs-into-holes packing for several membrane proteins
Membr Biochem.
1978.
Abstract
We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with hydrophobic exteriors and with hydrogen bonds between the side chains of one alpha-helix and the side chains of its knobs-into-holes packed neighbors.
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