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Review
. 1978;2(1):1-16.
doi: 10.3109/09687687809063855.

Proposed knobs-into-holes packing for several membrane proteins

A K Dunker  1 , T C Jones
Affiliations
Review

Proposed knobs-into-holes packing for several membrane proteins

A K Dunker et al. Membr Biochem. 1978.

Abstract

We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with hydrophobic exteriors and with hydrogen bonds between the side chains of one alpha-helix and the side chains of its knobs-into-holes packed neighbors.

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