Abstract

PIP: This is a comprehensive review of the literature dealing with the use of PGs (prostaglandins) to induce labor contractions or abortion. Many graphed bodily responses are used to illustrate the discussion. The functional character of the pregnant human uterus is described. It is theorized, from a review of many studies, that the pregnant human uterus is intrinsically active, but endogenously suppressed. Abortion or labor occur when the suppressor is removed, allowing the intrinsic stimulation within the uterus to operate. The uterus is capable at all times of synthesizing PG; the rate of synthesis depends on the amount of stretch. The administration of PG depends on time for its stimulating effect. Clinical trials have been conducted with various routes of PG administration. Current clinical studies being conducted in the field are reviewed. Evidently, saline solution causes abortion through the same mechanism as PGs, i.e., stimulation of the myometrium. Intrauterine PG therapy will remain the treatment of preference. Work is also being carried out in the mobilization of endogenous PGs.