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. 1973 Oct 5;182(4107):74-5.
doi: 10.1126/science.182.4107.74.

Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines

S P Banerjee, S H Snyder

Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines

S P Banerjee et al. Science. .

Abstract

A variety of mammalian and avian tissues N- and O-methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S-adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.

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