doi: 10.1017/s0022149x00005691.
The effect of praziquantel on Schistosoma mansoni
- PMID: 458128
- DOI: 10.1017/s0022149x00005691
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The effect of praziquantel on Schistosoma mansoni
J Helminthol.
1979 Mar.
Abstract
3 x 10(-6)M praziquantel fails to completely paralyse miracidia and cercariae in a short time but they are not infective when maintained in the solution. 3 x 10(-5)M praziquantel prevents infected snails shedding cercariae but does not kill daughter sporocyts or developing cercariae. As the action of praziquantel on adult worms is not blocked by 10(-2)M mecamylamine, pempidine or carbachol, but is reduced by calcium depletion, it is suggested that praziquantel may act by permitting calcium influx to muscle cells causing them to contract.
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