Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Jun;47(6):1297-305.
doi: 10.1161/01.cir.47.6.1297.

Variations in arterial blood pressure after kidney transplantation. Relation to renal function, plasma renin activity, and the dose of prednisone

M M Popovtzer, W Pinnggera, F H Katz, J L Corman, J Roninette, B Lanois, C G Haglrimson, T E Starzel

Variations in arterial blood pressure after kidney transplantation. Relation to renal function, plasma renin activity, and the dose of prednisone

M M Popovtzer et al. Circulation. 1973 Jun.

Abstract

The course of hypertension within the first 2 months after kidney transplantation was correlated with renal function, plasma renin activity (PRA), and the daily maintenance dose of prednisone in 18 homograft recipients. During acute rejection blood pressure (BP) closely correlated with PRA. Patients with normal homograft function showed an increase in BP early after transplantation which in most returned to normal 3–8 weeks later. In the latter group no correlation could be found between the level of BP and PRA, however the BP correlated closely with the dose of prednisone. These observations suggest that during acute rejection the increase in BP may at least partly be mediated by a renal pressor mechanism, whereas with normal renal function the high dose of glucocorticoids may play an important role in the development of hypertension.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The relationship between diastolic blood pressure and the maintenance dose of prednisone in patients with adequate kidney function.
Figure 2
Figure 2
Diastolic blood pressure and plasma renin activity in patients with adequate renal function.
Figure 3
Figure 3
The relationship between diastolic blood pressure and plasma renin activity in patients undergoing acute rejection.
See this image and copyright information in PMC

References

    1. Starzl TE. Experience in renal transplantation. Philadelphia: WB Saunders Co; 1964.
    1. Starzl TE, Marchioro TL, Terasaki PL, Porter KA, Faris TO, Herrmann TJ, Vredevoe DL, Hutt MP, Ogden DA, Waddell WR. Chronic survival after human renal transplantation. Ann Surg. 1965;162:749. - PMC - PubMed
    1. Blaufox MD, Birbari AE, Hickler RB, Merrill JP. Peripheral plasma renin activity in renal homotransplant recipients. New Eng J Med. 1966;275:1165. - PubMed
    1. Merrill JP. In: York Mecoff J., editor. Homotransplantation kidney and other tissues; Proceedings of the 96th Annual Conference on the Kidney; Pennsylvania: Marple Press Co; 1966. p. 165.
    1. Hume DM. Progress in clinical transplantation. In: Welch CE, editor. Advances in Surgery. vol 2. Chicago: Year Book Medical Publisher; 1966. p. 419. - PubMed