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. 1973 Nov 1;138(5):1065-76.
doi: 10.1084/jem.138.5.1065.

Requirement for alpha-L-fucose on the macrophage membrane receptor for MIF

H G Remold

Requirement for alpha-L-fucose on the macrophage membrane receptor for MIF

H G Remold. J Exp Med. .

Abstract

alpha-L-fucose abolishes the activity of guinea pig migration inhibitory factor (MIF) on the macrophages. Other sugars such as alpha-D-glucose, beta-D-galactose, alpha-L-rhamnose, methyl-alpha-D-mannoside, and N-acetyl-beta-D-glucosamine had no effect. Theabolition of MIF activity by alpha-L-fucose was reversible. When macrophages were incubated with alpha-L-fucosidase, a glycosidase which splits terminal alpha-L-fucose from oligosaccharides, the macrophages no longer responded to MIF. On the other hand, MIF incubated with alpha-L-fucosidase was still active. These experiments strongly suggest that alpha-L-fucose comprises an essential part of a macrophage membrane receptor for MIF.

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