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Clinical Trial
. 1973 Oct 13;4(5884):82-4.
doi: 10.1136/bmj.4.5884.82.

Double-blind cross-over study of ketoprofen and ibuprofen in management of rheumatoid arthritis

S B Mills, M Bloch, F E Bruckner
Clinical Trial

Double-blind cross-over study of ketoprofen and ibuprofen in management of rheumatoid arthritis

S B Mills et al. Br Med J. .

Abstract

A double-blind cross-over study of ketoprofen (Orudis) 150 mg daily and ibuprofen (Brufen) 1,200 mg daily was carried out in 35 outpatients with rheumatoid arthritis. Results suggest that analgesic and anti-inflammatory activity of ketoprofen is superior to that of ibuprofen. Significantly greater pain relief (P < 0.05) and reduction in joint circumference (P < 0.01) was obtained with ketoprofen than with ibuprofen. Side effects of the drugs were comparable and not serious.

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