Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Nov;116(2):818-22.
doi: 10.1128/jb.116.2.818-822.1973.

Modification of ribosomes in cryptopleurine-resistant mutants of yeast

L Skogerson, C McLaughlin, E Wakatama

Modification of ribosomes in cryptopleurine-resistant mutants of yeast

L Skogerson et al. J Bacteriol. 1973 Nov.

Abstract

Cryptopleurine-resistant mutants of Saccharomyces cerevisiae were isolated. A single, recessive nuclear gene, very closely linked to the mating locus (2.1 centimorgans), is responsible for resistance. Ribosomes from the mutants were found to be resistant to cryptopleurine when analyzed by poly(U)-directed polyphenylalanine synthesis. Analysis of the distribution of ribosomes between monosomes and polysomes in sensitive cells exposed to cryptopleurine suggests that some step is inhibited during the elongation phase of protein synthesis.

PubMed Disclaimer

References

    1. Genetics. 1966 Jan;53(1):165-73 - PubMed
    1. J Bacteriol. 1967 May;93(5):1662-70 - PubMed
    1. Biochem Biophys Res Commun. 1968 Apr 5;31(1):104-9 - PubMed
    1. Biochem Biophys Res Commun. 1968 Nov 8;33(3):368-73 - PubMed
    1. J Bacteriol. 1968 Nov;96(5):1664-71 - PubMed

LinkOut - more resources