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Clinical Trial
. 1973 Oct 20;4(5885):156-8.
doi: 10.1136/bmj.4.5885.156.

Influence of selection of patients on results of clinical trials

J P Leff
Clinical Trial

Influence of selection of patients on results of clinical trials

J P Leff. Br Med J. .

Abstract

The hypothesis is advanced that any population of patients can be divided into those with a good prognosis, a poor prognosis, and an intermediate prognosis in respect to a particular treatment. The outcome of a clinical trial of treatment will be partly determined by the proportion of patients selected for the trial from each of these prognostic groups. The implications of the hypothesis are illustrated by consideration of three recent trials of treatment for psychiatric patients.

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References

    1. Lancet. 1972 Oct 21;2(7782):854-5 - PubMed
    1. Psychol Med. 1973 Feb;3(1):5-17 - PubMed
    1. Br Med J. 1973 Mar 17;1(5854):633-7 - PubMed

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